A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions |
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Authors: | Nazia Kausar Abdulla Al Masum Md Maidul Islam Asish R Das |
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Institution: | 1.Department of Chemistry,University of Calcutta,Kolkata,India;2.Department of Chemistry,Aliah University,Kolkata,India |
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Abstract: | A catalyst-free green methodology for the synthesis of pharmacologically important spirooxindole derivatives has been developed by a three-component domino reaction between isatin, various amino compounds, and 1,3-dicarbonyl or 3-phenylisoxazolone compounds in ethyl l-lactate medium at room temperature. This new efficient synthetic method facilitated the formation of a wide range of biologically significant spirooxindole derivatives (including 17 new spirooxindoles) under very mild conditions. The cytotoxic activity of one of the isoxazole-fused spirooxindoles was evaluated in MDA-MB 468 breast cancer cell line. It was found that cell survivability decreases with increasing concentration of the selected compound in MDA-MB 468 breast cancer cells. |
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