Iodoamination of Alkenyl Sulfonamides by Potassium Iodide and Hydrogen Peroxide in Aqueous Medium |
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| Authors: | Sabrina Giofr ,Roberto Sala,Egle Maria Beccalli,Leonardo Lo Presti,Gianluigi Broggini |
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| Affiliation: | Sabrina Giofrè,Roberto Sala,Egle Maria Beccalli,Leonardo Lo Presti,Gianluigi Broggini |
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| Abstract: | A procedure for the iodoamination of unfunctionalized olefins tethered to a tosyl‐protected NH‐group has been developed. The combined use of KI and H2O2 in aqueous medium was effective for the preparation of iodomethyl‐substituted nitrogen‐containing heterocycles. The selective exo‐trig iodocyclization provided 1,2‐bifunctional 5‐, 6‐, and 7‐membered cyclic skeletons. |
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| Keywords: | cyclization amination nitrogen heterocycles synthetic methods sulfonamides |
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