Radiation-induced changes in carboxymethylated chitosan |
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| Authors: | Ling Huang Jing Peng Maolin Zhai Jiuqiang Li Genshuan Wei |
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| Affiliation: | aBeijing National Laboratory for Molecular Sciences, Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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| Abstract: | This study focuses on the radiation effect of γ-ray on carboxymethylated chitosan (CM-chitosan) in solid state. The changes in molecular weight of CM-chitosan with absorbed dose were monitored by viscosity method. Experimental results indicated that random chain scissions took place under irradiation. Radiation chemical yield (Gd) of CM-chitosan in solid state with N2-saturated was 0.49, which showed CM-chitosan has high radiation stability. Biomaterials composed of CM-chitosan can be thought to sterilize with low absorbed dose. FTIR and UV spectra showed that main chain structures of CM-chitosan were retained, carbonyl/carboxyl groups were formed and partial amino groups were eliminated in high absorbed dose. XRD patterns identified that the degradation of CM-chitosan occurred mostly in amorphous region. |
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| Keywords: | Carboxymethylated chitosan γ -ray Radiation effect |
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