| 离子色谱法测定盐酸贝那普利片的含量 |
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| 引用本文： | 楼超艳,薛 宇,朱 岩,周 丹. 离子色谱法测定盐酸贝那普利片的含量[J]. 中国无机分析化学, 2013, 3(3): 64-66 |
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| 作者姓名： | 楼超艳 薛 宇 朱 岩 周 丹 |
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| 作者单位： | 浙江大学理学院化学系,浙江大学理学院化学系,浙江大学理学院化学系,桂林理工大学 |
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| 基金项目： | 浙江省大学生科技创新项目计划(2012R401030) |
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| 摘 要： | 建立离子色谱法测定盐酸贝那普利片含量的方法。实验中选定了最佳的色谱条件为淋洗液:甲烷磺酸(6mmol/L)-乙腈(35%),流速:1.0mL/min,柱温:25℃,进样量:7μL。实验表明,贝那普利在0.5~25μg/mL范围内线性关系良好,相关系数r为0.999 9,检测限为0.089μg/mL,加标回收率为97.96%。方法操作简单,灵敏度高、准确、重现性好,可用于盐酸贝那普利片含量的测定。
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| 关 键 词： | 离子色谱法 盐酸贝那普利 甲烷磺酸 |
| 收稿时间： | 2013-04-10 |
| 修稿时间： | 2013-04-25 |
Determination of Benazepril Hydrochloride Tablets by Ion Chromatography |
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| LOU Chaoyan,XUE Yu,ZHU Yan and ZHOU Dan. Determination of Benazepril Hydrochloride Tablets by Ion Chromatography[J]. Chinese Journal of Inorganic Analytical Chemistry, 2013, 3(3): 64-66 |
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| Authors: | LOU Chaoyan XUE Yu ZHU Yan ZHOU Dan |
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| Affiliation: | Department of Chemistry,College of Science, Zhejiang University,Department of Chemistry,College of Science, Zhejiang University,Department of Chemistry,College of Science, Zhejiang University,Guilin Science University |
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| Abstract: | A method for the determination of benazepril hydrochloride tablets by ion chromatography（IC） was established. The optimal chromatographic conditions were found as following, the mixture solution of methanesulfonic acid （6 mmol/L） and aeetonitrile （85%） was used as mobile phase; a flow rate was 1 mL/min; column temperature was 25 ℃, the injection volume was 7 μL. The experimental results indicated that the calibration curve of benazepril hydrochloride has a good linearity in the range of 0.5 25 μg/mL with the correlation coefficients of 0. 999 9. The average recovery of benazepril hydrochloride was 97.96% and the LOD was 0. 089 μg/mL. The method is proved to be simple, highly sensitive, accurate, and have a good repeatability, thus is suitable for evaluating the quality of benazepril hydrochloride tablets. |
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| Keywords: | Ion chromatography benazepril hydrochloride |
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