Synthesis of a key precursor for orienticin C and model study on ruthenium-mediated macrocyclization |
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| Authors: | Pearson Anthony J Ciurea Diana V |
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| Affiliation: | Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA. ajp4@case.edu |
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| Abstract: | A tripeptido--arene--ruthenium complex was prepared as a key precursor for the projected synthesis of orienticin C, demonstrating that the cyclopentadienylruthenium moiety can be attached to a chloroarene in the presence of multiple functionality. The ruthenium-mediated intramolecular SNAr reaction for formation of the required diaryl ether linkage was successfully tested on a model system. |
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