POLYETHYLENE GLYCOL-MODIFIED HEMATOPORPHYRIN AS PHOTOSENSITIZER |
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| Authors: | Yoh Kodera Ayako Ajima Katsunobu Takahashi Ayako Matsushima Yuji Saito Yuji Inada |
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| Affiliation: | Laboratory of Biological Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152, Japan |
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| Abstract: | Abstract— Hematoporphyrin, having two carboxylic groups, was coupled with α-(3-aminopropyl)-ω-methoxypoly(oxyethylene), PEG-NH2, through acid-amide bond formed with carbodtimide. PEG-modified hematoporphyrin was readily soluble not only in neutral aqueous solution but also in organic solvents. Its absorption spectrum showed a sharp band at 376 nm in neutral aqueous solution and at 403 nm in benzene. Modified hematoporphyrin acted as a photosensitizer; imidazole and indole were photooxidized in organic solvents such as benzene or chloroform, and uric acid was also photooxidized in neutral aqueous solution. |
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