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The first total synthesis of (−)-bitungolide E |
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| Authors: | J. ShashidharK. Mahender Reddy Subhash Ghosh |
| Affiliation: | Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | The first total synthesis of (−)-bitungolide E is described. The key steps include a Myers’ alkylation, modified Evans’ syn aldol-reaction, using Crimmins protocol, Sharpless asymmetric epoxidation and ring-closing metathesis reaction. |
| Keywords: | Bitungolides Dual specificity VHR phosphatase Myers&rsquo alkylation Sharpless epoxidation Ring closing metathesis Evans&rsquo 1,3-anti reduction |
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