Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia |
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| Authors: | Pan Li Terrazas Cesar Lezama-Davila Claudio M Rege Nirmala Gallucci Judith C Satoskar Abhay R Kinghorn A Douglas |
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| Institution: | Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Department of Pathology, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA. |
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| Abstract: | Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs). |
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