From molecular level to macroscopic properties: A solid-state NMR biomineralization and biomimetic exploration |
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| Institution: | 1. Departamento de Salud Pública Facultad de Medicina UNAM, Ciudad Universitaria Coyoacán 04510, D.F., Mexico;2. Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato Oncología e Investigación, Hospital Infantil de México Federico Gómez 06720, D.F., Mexico;3. Department of Chemistry and Biochemistry, Arizona State University, Physical Sciences BLDG D-102, Tempe, AZ 85287, USA;4. Instituto de Fisiología Celular UNAM, Ciudad Universitaria Coyoacán 04510, D.F., Mexico;5. Instituto de Química UNAM, Ciudad Universitaria Coyoacán 04510, D.F, Mexico;1. Faculty of Arts and Science, Kyushu University, Fukuoka 819-0395, Japan;2. Department of Chemistry, Faculty of Science, Kyushu University, Fukuoka, 819-0395, Japan;1. Department of Mechanical Engineering, University of Hawaii at Manoa, Honolulu, HI 96822, United States;2. Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96826, United States;1. Universidad de Granada, Departamento de Física Aplicada, C. U. Fuentenueva, E-18071 Granada, Spain;2. Universidad de Granada, Departamento de Química Orgánica, Unidad de Excelencia Química Aplicada a Biomedicina y Medioambiente, C. U. Fuentenueva, E-18071 Granada, Spain;3. Instituto de Investigación Biosanitaria Ibs.GRANADA, Spain |
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| Abstract: | Through biomineralization, calcareous composites are produced with exceptional properties, evolution-optimized for specific function. The bioinspired quest to understand how properties are controlled and enhanced is motivated by their fundamental and technological significance. The incorporation of small molecules and/or biopolymers as inter- and intra-crystalline additives in the CaCO3 matrix, is widely employed by organisms to achieve diverse functions. The interactions between the components during the early events within the precipitation medium, and when entrapped through precipitation-crystallization, are key players of process–property regulation. In addition to identifying the bulk matrices and the incorporated molecules, we show how solid-state NMR methods are tailored to directly report the chemical-structural details of the inorganic interface that surrounds an occlusion. Solid-state NMR is uniquely suited for that and is applicable to stable or spontaneously transforming lattices, crystalline or amorphous. Our findings are grouped to highlight the connection between the molecular level and tunability of macroscopic properties. |
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| Keywords: | Biomineralization Solid-state NMR REDOR TEDOR Intracrystalline Occlusions |
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