Lipids and lipid mixtures in boundary layers: From hydration lubrication to osteoarthritis |
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| Affiliation: | 1. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, United States;2. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States;3. Department of Materials Science and Engineering, Cornell University, Ithaca, NY, United States;4. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States;1. KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Surface and Corrosion Science, Drottning Kristinas väg 51, SE-10044 Stockholm, Sweden;2. RISE Research Institutes of Sweden, Division of Bioscience and Materials, SE-114 86 Stockholm, Sweden;3. Helmholtz-Zentrum Geesthacht: Centre for Materials and Costal Research, Institute of Materials Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany;4. Institute of Mathematics and Physics, UTP University of Science and Technology, al. Kaliskiego 7, 85-796 Bydgoszcz, Poland;5. Institute for Multiscale Simulation, Cluster of Excellence “Engineering of Advanced Materials”, Friedrich-Alexander Universität Erlangen-Nürnberg, Cauerstrasse 3, 91058 Erlangen, Germany;1. Canadian Research Chair in Bioinspired materials, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada;2. School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea;3. Department of Chemistry, Center for Macromolecular Engineering, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States;4. School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea |
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| Abstract: | The hydration layer surrounding the phosphocholine headgroups of single-component phosphatidylcholine lipids, or of lipid-mixtures, assembled at an interface greatly modifies the interfacial properties and interactions. As water molecules within the hydration layer are held tightly by the headgroup but are nonetheless very fluid on shear, the boundary lipid layers, exposing the highly hydrated headgroup arrays, can provide efficient boundary lubrication when sliding against an opposing surface, at physiologically high contact pressures. In addition, any free lipids in the surrounding liquid can heal defects which may form during sliding on the boundary phosphatidylcholine layer. Similar boundary lipid layers contribute to the lubricating, pressure-bearing, and wear-protection functions of healthy articular joints. This review presents a survey of the relationship between the molecular composition of the interfacial complex and the lubrication behavior of the lipid-based boundary layers, which could be beneficial for designing boundary lubricants for intra-articular injection for the treatment of early osteoarthritis. |
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| Keywords: | Lipids Lipid mixtures Boundary lubrication Interfacial layer Hydration lubrication Cartilage lubrication Osteoarthritis |
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