Asymmetric Morita-Baylis-Hillman reactions of 2-cyclohexen-1-one catalyzed by chiral biaryl-based bis(thiourea) organocatalysts |
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| Authors: | Yuki NakayamaTakashi Gotanda Katsuji Ito |
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| Institution: | Department of Chemistry, Fukuoka University of Education, Akama, Munakata, Fukuoka 811-4192, Japan |
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| Abstract: | Newly-developed bis(thiourea) 1d was found to be an efficient organocatalyst for the Morita-Baylis-Hillman reaction. High enantioselectivities were obtained in the reaction of 2-cyclohexen-1-one with both aromatic aldehydes (up to 84% ee) and aliphatic aldehydes (up to 96% ee). |
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| Keywords: | Organocatalyst Allylic alcohol Morita-Baylis-Hillman reaction Bis(thiourea) |
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