Less common applications of simulated moving bed chromatography in the pharmaceutical industry |
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Authors: | Huthmann E Juza M |
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Institution: | CarboGen (Aarau) AG, Schachenallee 29, CH-5001 Aarau, Switzerland. |
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Abstract: | Simulated moving bed (SMB) chromatography is often perceived in the pharmaceutical industry as chromatographic method for separating binary mixtures, like racemates. However, SMB can also be used for unbalanced separations, i.e. binary mixtures of varying compositions and multi-component mixtures. These less common application modes of isocratic SMB chromatography are exemplified for four different compounds (racemates and diastereomers) and discussed in view of the so-called 'triangle theory' from an industrial perspective. |
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Keywords: | Simulated moving bed chromatography Preparative HPLC Chiral separation Enantiomer separation Chiral discrimination |
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