A new synthesis of 2-substituted pyridines via aluminum chloride induced heteroarylation of arenes and heteroarenes |
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| Authors: | Pal Manojit Batchu Venkateswara Rao Dager Indu Swamy Nalivela Kumara Padakanti Srinivas |
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| Affiliation: | Chemistry-Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, India. manojitpal@drreddys.com |
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| Abstract: | [reaction: see text] We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through AlCl(3)-induced C-C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substituted pyridines in good yields. |
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