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A novel, base-labile fluorous amine protecting group: synthesis and use as a tag in the purification of synthetic peptides |
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| Authors: | Peter C de Visser Marcel van HeldenDmitri V Filippov Gijsbert A van der MarelJan W Drijfhout Jacques H van BoomDaan Noort Herman S Overkleeft |
| Institution: | a Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands b Leiden University Medical Center, Leiden University, PO Box 9600, 2300 RC Leiden, The Netherlands c TNO Prins Maurits Laboratory, PO Box 45, 2280 AA Rijswijk, The Netherlands |
| Abstract: | A new, base-labile fluorous tag based on the Msc amine protecting group was synthesized. Its use in the purification of synthetic peptides by fluorous HPLC or fluorous SPE was demonstrated. |
| Keywords: | fluorous Msc protecting group synthetic peptides purification |
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