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Highly regioselective palladium/copper-catalysed cross-coupling reactions of terminal alkynes and allenes
Authors:Didier BruyereRonald Grigg  Joanne HinsleyRuksana K Hussain  Stewart KornCecilia Orgaz De La Cierva  Visuvanathar SridharanJung Wang
Institution:a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds University, Leeds LS2 9JT, UK
b Avecia Lifesciences Molecules, PO Box 521, Leeds Road, Huddersfield HD2 1GA, UK
Abstract:The Pd/Cu-catalysed cross-coupling reaction of heterocyclic terminal alkynes and allene/allenyl heterocycles affords novel trisubstituted en-ynes in good yield.
Keywords:bimetallic catalysis  en-ynes  peptidomimetics  trisubstituted alkenes
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