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A new synthetic entry to the tricyclic skeleton of FR901483 by palladium-catalyzed cyclization of vinyl bromides with ketone enolates |
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| Abstract: | A new synthetic entry to the FR901483 core is described. The Pd-mediated cyclization of amino-tethered vinyl halides and ketone enolates from the azaspiro4.5]decan-8-ones 5 and 10 gives the functionalized 7,10a-methanoperhydropyrrolo1,2-a]azocines 1 and 11, respectively. |
| Keywords: | alkenylation FR901483 nitrogen heterocycles palladium spiro compounds |
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