Solid phase synthesis of amides by the Beckmann rearrangement of ketoxime carbonates |
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Authors: | Sarah HisChristophe Meyer Janine Cossy Gibert EmericAlfred Greiner |
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Affiliation: | a Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France b Bayer Cropscience SA, La Dargoire Research Center, 14-20 rue Pierre Baizet, BP 9163, Lyon Cedex 09, France |
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Abstract: | In the presence of trifluoroacetic acid, ketoxime benzyl carbonates undergo a Beckmann rearrangement to the corresponding amides. This reaction was translated to a solid support by immobilizing oximes in the form of mixed carbonates derived from hydroxymethylpolystyrene in order to produce a diversity of amides with high efficiency. |
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