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Total synthesis of macrosphelide A by way of palladium-catalyzed carbonylative esterification |
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| Authors: | Shin-ichi KusakaSuguru Dohi Takayuki DoiTakashi Takahashi |
| Institution: | Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro, Tokyo 152-8552, Japan |
| Abstract: | We achieved the total synthesis of macrosphelide A, as part of a combinatorial library of its analogues. The key intermediate, the seco-acid derivative, was prepared from the corresponding vinyl iodide using sequential carbonylative esterification. |
| Keywords: | macrolactone palladium catalyst carbonylation natural product synthesis |
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