RuCl3-promoted amide formation from azides and thioacids |
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Authors: | Fabio FazioChi-Huey Wong |
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Institution: | Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA |
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Abstract: | Described here is the Ru(III)-promoted amide formation from azides and thioacids, which were shown not to form amides at room temperature in the absence of ruthenium. We believe that a complex formed by Ru(III) increases the reactivity of the thiocarbonyl species and therefore reaction with azides occurs at room temperature, even when less reactive (electron rich and/or sterically hindered) azides are employed. |
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Keywords: | ruthenium trichloride amide formation thioacids azides |
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