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(E)-Selective Horner-Wadsworth-Emmons reaction of aryl alkyl ketones with bis(2,2,2-trifluoroethyl)phosphonoacetic acid |
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| Authors: | Shigeki Sano Yuka TakemotoYoshimitsu Nagao |
| Institution: | Faculty of Pharmaceutical Sciences, The University of Tokushima, Sho-machi, Tokushima 770-8505, Japan |
| Abstract: | The stereoselective Horner-Wadsworth-Emmons reaction of aryl alkyl ketones with bis(2,2,2-trifluoroethyl)phosphonoacetic acid utilizing lithium hexamethyldisilazide in DMF afforded (E)-α,β-unsaturated carboxylic acids as the major products. |
| Keywords: | Horner-Wadsworth-Emmons reactions olefination stereoselection α β-unsaturated carboxylic acids α β-unsaturated esters Wittig reactions |
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