Synthesis of 2′-O,3′-O bicyclic adenosine analogues using ring closing metathesis |
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| Authors: | Patricia BuscaMélanie Etheve-Quelquejeu Jean-Marc Valéry |
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| Institution: | Structure et Fonction de Molécules Bioactives-UMR CNRS 7613-Equipe ?Chimie des Glucides?, Université Pierre et Marie Curie, 4 place Jussieu, case 179, 75252 Paris Cedex 05, France |
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| Abstract: | The synthesis of 2′-O,3′-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs’ catalyst. The Z and E isomers were purified and characterised. |
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| Keywords: | ligases nucleosides ring closure metathesis |
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