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Catalytic cyclopropanation of methylenecyclobutanes using ethyl nitrodiazoacetate. Synthesis of spirohexane amino acids |
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| Authors: | Nikolai V YashinElena B Averina Sergei M GerdovTamara S Kuznetsova Nikolai S Zefirov |
| Institution: | Department of Chemistry, Moscow State University, 119899 Moscow, Russia |
| Abstract: | The reaction of ethyl nitrodiazoacetate with a series of methylenecyclobutanes was studied and both 1+2]- and 2+3]-cycloaddition pathways were observed depending on olefin structure. Amino acids of a spirohexane type were synthesized from methylenecyclobutanes by a three-step synthesis. |
| Keywords: | ethyl nitrodiazoacetate spirohexane amino acids [1+2]-cycloaddition [2+3]-cycloaddition 1-ethoxycarbonyl-nitropolyspirocycloalkanes |
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