A highly active catalyst system for the heteroarylation of acetone |
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| Authors: | Ping Liu Thomas J Lanza JrJames P Jewell Carrie P JonesWilliam K Hagmann Linus S Lin |
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| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA |
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| Abstract: | A highly active catalyst system for the heteroarylation of acetone has been identified. The coupling between the in situ generated tributyltin enolate of acetone and a variety of heteroaromatic bromides, chlorides, and triflates in the presence of this catalyst system provided arylacetones in good yields. |
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