An efficient palladium catalyzed synthesis of 2-arylbenzothiazoles |
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Authors: | Vattoly J MajoJaya Prabhakaran JJohn MannJS Dileep Kumar |
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Institution: | Department of Psychiatry/Neuroscience, NYSPI/Columbia University, 1051 Riverside Drive, New York, NY 10032, USA |
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Abstract: | A novel and convergent palladium catalyzed synthesis of 2-arylbenzothiazoles has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 2-bromobenzothiazole with aryl boronic acids to provide a variety of 2-arylbenzothiazole derivatives in good yield. The synthetic utility of this methodology is demonstrated by the synthesis of 2-(4-aminophenyl)-6-methoxybenzothiazole, a PET probe precursor for the in vivo imaging of Alzheimer's disease. |
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Keywords: | boronic acid benzothiazole Suzuki coupling palladium |
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