Differential sacnning calorimetric examination of the human intervertebral disc: establishment of calorimetric standards of different stages of degeneration |
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Authors: | I DománT Illés D Lorinczy |
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Institution: | a Department of Orthopaedic Surgery, Medical and Health Sciences Centre, H-7624 Pecs, Hungary b Institute of Biophysics, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pecs, Hungary |
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Abstract: | Intervertebral disc (IVD) degeneration is a common orthopaedic disorder with significant social and economic impact. The major pathological changes occur in the structure of anulus fibrosus (AF) and nucleus pulposus (NP). According to previous reports differential sacnning calorimetric (DSC) proved to be a suitable method for the demonstration of thermal consequences of local and global conformational changes in the structure of the human intervertebral discs. According to the present study, the DSC results clearly proved that definitive differences are present between the stages of disc degeneration in calorimetric measures. The structural differences between the stages could be also demonstrated by histology. |
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Keywords: | DSC Intervertebral disc Degeneration Anulus fibrosus Nucleus pulposus |
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