Novel analogues of 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: modifications in the dioxane ring |
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| Authors: | José M Bartoloméa Jesús AlcázarJIgnacio Andrés Marcel De BruynJavier Fernández Encarna MatesanzKristof Van Emelen |
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| Institution: | a Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen-Cilag S.A., Medicinal Chemistry Dept., Jarama s/n, 45007 Toledo, Spain
b Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen Pharmaceutica N. V., Medicinal Chemistry Dept., Turnhoutseweg 30, B-2340 Beerse, Belgium |
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| Abstract: | The synthesis of a series of novel analogues of the 3-substituted-2,3-dihydro-1,4-dioxino2,3-b]pyridine core, modified in the non-aromatic ring, is described. Due to the presence of a versatile hydroxymethyl group in their structure, these novel scaffolds are attractive intermediates for the preparation of potential new therapeutic agents. |
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