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Convergent multicomponent assembly of 2-acyloxymethyl thiazoles |
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| Authors: | Bernd HenkelBarbara Beck Benedikt WestnerBeatrice Mejat Alexander Dömling |
| Institution: | Morphochem AG, Gmunder Str. 37-37a, 81379 München, Germany |
| Abstract: | Diverse substituted 2-acyloxymethyl thiazoles can be assembled by a new multicomponent reaction (MCR) of methyl 3-(N,N-dimethylamino)-2-isocyanoacrylate, aldehydes and thiocarboxylic acid under Lewis acid catalysis. The reaction is performed under mild conditions and is compatible with a wide range of functionalized starting materials. 13 examples are given. |
| Keywords: | isocyanide multicomponent reaction thiazole Passerini reaction |
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