An efficient route to 4-(substituted benzyl)piperidines |
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| Authors: | Bart?omiej Furman Magdalena Dziedzic |
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| Affiliation: | Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland |
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| Abstract: | A novel approach to 4-(substituted benzyl)piperidines has been developed. The key steps involve the cyclization of imines bearing an allylsilane in the side-chain followed by the palladium-catalyzed cross-coupling of the resulting 4-methylenepiperidine with organoboronic acids under an atmosphere of oxygen. |
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| Keywords: | cyclisation piperidines Heck reaction |
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