| 盐酸依匹斯汀PVC膜电极的研制及应用 |
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| 引用本文： | 徐刚,任凌燕,陈楠.盐酸依匹斯汀PVC膜电极的研制及应用[J].分析试验室,2010,29(1). |
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| 作者姓名： | 徐刚 任凌燕 陈楠 |
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| 作者单位： | 重庆科技学院现代生物技术研究所,重庆,401331 |
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| 基金项目： | 重庆市自然科学基金(CSTC2007BB7215)项目资助 |
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| 摘 要： | 以四苯硼酸钠与盐酸依匹斯汀生成的离子缔合物为电活性物质,研制了盐酸依匹斯汀PVC膜选择性电极。在pH 5的HCl-NaOH溶液中,电极的线性范围为6.3×10-7~1.0×10-1mol/L,斜率为49 mV/pC(10℃),检出限为1.89×10-7mol/L。应用此电极测定药物中盐酸依匹斯汀含量,RSD3%,回收率为97.5%~100.2%。
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| 关 键 词： | 盐酸依匹斯汀 PVC膜电极 研制 应用 |
Preparation and application of the PVC membrane epinastine hydrochloride selective electrode |
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| XU Gang,REN Ling-yan,CHEN Nan.Preparation and application of the PVC membrane epinastine hydrochloride selective electrode[J].Chinese Journal of Analysis Laboratory,2010,29(1). |
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| Authors: | XU Gang REN Ling-yan CHEN Nan |
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| Institution: | Institute of Modern Biotechnology;Chongqing University of Science and Technology;Chongqing 401331 |
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| Abstract: | A PVC membrane selective electrode was prepared. The ion-associate of epinastine hydrochloride with sodium tetraphenylborate was used as the membrance carrier. The electrode shows a linear Nernst response in the range of 6.3×10~(-7)～1.0×10~(-1) mol/L and the slope is 49 mV/pC, and the detection limit is 1.89×10~(-7) mol/L in hydrochloric acid-sodium hydroxide buffer solution of pH 5.0 at 10 ℃. This electrode exhibits a quick response with good reproducibility. It was successfully applied to the determination of epinastine hydrochloride in drugs. The relative standard deviation is less than 3%, and the recoveries are 97.5%～100.2%. The results are reliable. |
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| Keywords: | Epinastine hydrochloride PVC membrane electrode Preparation Application |
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