Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy |
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Authors: | Kong Jongrock Chen Cheng-yi Balsells-Padros Jaume Cao Yang Dunn Robert F Dolman Sarah J Janey Jacob Li Hongmei Zacuto Michael J |
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Affiliation: | Department of Process Research, Merck Research Laboratory, Rahway, New Jersey 07065, USA. jongrock_kong@merck.com |
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Abstract: | A highly efficient synthesis of Vaniprevir (MK-7009) has been accomplished in nine linear steps and 55% overall yield. The key features of this synthesis include a cost-effective synthesis of the isoindoline subunit and efficient construction of the 20-membered macrocyclic core of Vaniprevir (MK-7009) utilizing ring-closing metathesis technology. A high-performing ring-closing metathesis protocol has been achieved by simultaneous slow addition of the ruthenium catalyst (0.2 mol %) and the diene substrate at a concentration of 0.13 M. |
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