Monoacylglycerols as transmembrane Cl- anion transporters |
| |
Authors: | Bahmanjah Soheila Zhang Ning Davis Jeffery T |
| |
Institution: | Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. |
| |
Abstract: | We report that the amphiphilic natural product, monoacylglycerol 1, functions as a transmembrane Cl(-)/NO(3)(-) anion transporter. The 1,2-diol group is crucial for the transport function since diacylglycerol and triacylglycerol analogs are not anion transporters. Furthermore, adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl(-) membrane transport properties. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|