Palladium-catalyzed C-N cross coupling of sulfinamides and aryl halides |
| |
Authors: | Sun Xiaofei Tu Xingzhao Dai Chuan Zhang Xiaoping Zhang Binbin Zeng Qingle |
| |
Institution: | Institute of Green Catalysis and Synthesis, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. |
| |
Abstract: | The palladium-catalyzed C-N cross coupling of sulfinamides and aryl halides is reported. In the presence of Pd(2)(dba)(3), tBuXPhos, NaOH, and a small amount of water, the C-N cross coupling of chiral tert-butanesulfinamide and aryl halides was accomplished to give N-aryl tert-butanesulfinamide without racemization, and the coupling of racemic p-toluenesulfinamide smoothly afforded N-aryl p-toluenesulfinamides. 2-Bromopyridine was also suitable for the coupling. Addition of a small amount of water to the catalytic system was of importance to obtain high yields. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|