Chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines: new N,P-ligands for asymmetric catalysis |
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Authors: | Giorgio Chelucci Gianmauro Orrù |
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Institution: | Dipartimento di Chimica, Università di Sassari, via Vienna 2, I-07100 Sassari, Italy |
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Abstract: | Three chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines, as first representative examples of a new class of chiral N,P-ligands were prepared from (+)-nopinone, (+)-camphor and 5α-androst-2-en-17-one. These ligands have been assessed in the enantioselective palladium-catalysed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 74% has been obtained. |
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Keywords: | Phosphinopyridine ligands Chiral acridines Palladium catalysts Enantioselective allylic substitutions |
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