|
|||||
|
|
Pegylation of 1,4,8,11-tetraazacyclotetradecane (cyclam) and its Cu(II) complexation |
|
| Authors: | Holger Stephan Dietmar Appelhans Daniela Tabuani Brigitte Voit |
| Affiliation: | a Research Center Rossendorf Inc., Institute of Bioinorganic and Radiopharmaceutical Chemistry, PO Box 510 119, D-01328 Dresden, Germany b Research Center Rossendorf Inc., Institute of Radiochemistry, PO Box 510 119, D-01328 Dresden, Germany c Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden, Germany |
| Abstract: | Two novel star-like cyclam derivatives appended with four amino groups and four PEG-arms have been synthesised. The complex formation of cyclam and the two cyclam derivatives with Cu(II) has been studied by UV-vis and time-resolved laser-induced fluorescence (TRLFS) measurements outlining 1:1 complexes between cyclam ligands and Cu(II). By TRLFS measurements a quench effect of the Cu(II) on the fluorescence of the ligand was also found to determine the complex formation between Cu(II) and the ligands. |
| Keywords: | Cyclam Synthesis Complex formation Fluorescence |
| 本文献已被 ScienceDirect 等数据库收录！ | |