Tandem Michael addition and intramolecular aldol cyclization of 1,2-dideoxy-1-nitroheptitols derived from sugars |
| |
| Authors: | M.V. Berrocal,E. Romá n,J.A. Serrano,M.E. Light |
| |
| Affiliation: | a Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
b Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK |
| |
| Abstract: | The base-catalyzed Michael addition of primary nitro compounds derived from sugars with 2 equiv of methyl vinyl ketone or acrolein was followed, in situ, by an asymmetric intramolecular aldol cyclization, thus yielding 2-acyl-4-glyco-4-nitrocyclohexanol derivatives with high diastereoselectivity. |
| |
| Keywords: | Michael addition Aldol cyclization Nitro compounds Sugars |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
