Synthesis of fused bicyclic pyridines with microwave-assisted intramolecular hetero-Diels-Alder cycloaddition of acetylenic pyrimidines |
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Authors: | Bin Shao |
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Affiliation: | Purdue Pharma, L.P., Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA |
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Abstract: | A series of acetylenic pyrimidines was synthesized and subjected to microwave irradiation. In contrast to conventional heating, the microwave irradiations generally gave clean conversion to fused bicyclic pyridines for all substrates reported with shorter reaction time. This method has been successfully applied to the synthesis of both fused lactones and lactams. |
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Keywords: | Heterocycle Hetero-Diels-Alder cycloaddition Microwave Pyrimidine Acetylene Intramolecular |
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