Synthesis of α1-(Cbz-aminoalkyl)-α2-(hydroxyalkyl)phosphinic esters |
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| Authors: | Marcin Drag Józef Oleksyszyn |
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| Institution: | Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland |
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| Abstract: | A synthesis of α1-(Cbz-aminoalkyl)-α2-(hydroxyalkyl)phosphinic esters was achieved by the 1,2-addition of the appropriate aldehyde to Cbz-protected phosphinic analogues of amino acid esters in the presence of at least three equivalents of trimethylsilyl chloride and NEt3. The complete deprotection of the product esters could be achieved in one step using 35% HBr in acetic acid. |
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| Keywords: | Phosphinates Phosphinic esters Addition |
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