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An affinity-based probe for the proteomic profiling of aspartic proteases |
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| Authors: | Souvik Chattopadhaya Shao Q. Yao |
| Affiliation: | a Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore b Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore |
| Abstract: | We have developed an affinity-based probe for the proteomic profiling of aspartic proteases. Our probe was shown to be selective towards aspartic proteases over other proteins. It was also shown that the strategy may be used to label selectively aspartic proteases in the presence of a large excess of other proteins, thus making it useful for future proteome profiling experiments. |
| Keywords: | Affinity-based profiling Activity-based profiling Proteomics Aspartic proteases Enzymes Photolabile probe |
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