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Enantioselective conjugate addition of diethylzinc to acyclic enones using a copper phosphino-phenol complex as catalyst |
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| Authors: | Katsuji Ito Shuuichiro Eno Tsutomu Katsuki |
| Affiliation: | a Department of Chemistry, Fukuoka University of Education, Akama, Munakata, Fukuoka 811-4192, Japan b Department of Chemistry, Faculty of Science, Graduate School, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan |
| Abstract: | Newly designed phosphino-phenol 1c was found to be an efficient chiral auxiliary for copper-mediated asymmetric conjugate addition of diethylzinc to acyclic enones. High enantioselectivity up to >99% ee was achieved in the reaction of acyclic α,β-enones. |
| Keywords: | Copper Asymmetric catalysis Phosphino-phenol Conjugate addition |
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