Microwave assisted cyclocondensation of dialdehydes with chiral diamines forming calixsalen type macrocycles |
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Authors: | Sankareswaran Srimurugan Thirukkallam Kanthadai Varadarajan |
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Institution: | a Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India b Sophisticated Analytical Instrument Facility, Indian Institute of Technology Madras, Chennai 600 036, India |
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Abstract: | Microwave irradiation of various dialdehydes and chiral diamines afforded chiral macrocyclic imines in moderate to good yields. Linked dialdehydes predominantly form 2+2] macrocycles whereas dialdehydes without linkers yield 3+3] macrocycles. This is the first report of template-free synthesis of calixsalen-type macrocycles formed in shorter reaction times under microwave conditions. In all the reactions, the salts of chiral diamines were used in contrast to the free diamines normally employed. |
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Keywords: | Macrocycles Schiff bases Microwave |
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