Super fast cobalt carbonyl-mediated synthesis of ureas |
| |
Authors: | Per-Anders Enquist |
| |
Institution: | Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Box-574, SE-75123 Uppsala, Sweden |
| |
Abstract: | Fast cobalt carbonyl-mediated generation of ureas from primary amines was performed using high-density microwave irradiation. This enhanced method permitted the preparation of symmetrical ureas in good yields and unsymmetrical ureas in moderate yields. The reaction times varied between 10 s and 40 min. The proposed mechanism for the reaction includes in situ generation of an intermediate isocyanate that subsequently traps the free amine, producing the urea product. |
| |
Keywords: | Microwave Carbonylation Cobalt carbonyl Urea Isocyanate |
本文献已被 ScienceDirect 等数据库收录! |
|