The ‘fully protected backbone’ approach as a versatile tool for a new solid-phase PNA synthesis strategy |
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| Authors: | Gregory Upert |
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| Affiliation: | Laboratoire de Chimie Bioorganique, UMR UNSA-CNRS 6001, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, 06108 Nice Cedex 2, France |
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| Abstract: | The ‘fully protected backbone’ (FPB) strategy has been efficiently adapted to the solid-phase synthesis of homothymine, homocytosine and ‘mixed’ pyrimidine PNAs. This versatile and simple method avoids the preparation of PNA monomers and relies on easy available starting materials, highly efficient backbone elongations and effective nucleobase units condensations. |
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| Keywords: | PNA Solid-phase synthesis FPB strategy |
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