One-pot synthesis of cyclic enecarbamates from lactam carbamates |
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| Authors: | Jurong Yu Vu Truc Elizabeth Hierl |
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| Institution: | a Department of Process Research and Development, Bristol-Myers Squibb, New Brunswick, NJ 08903-0191, USA
b ResCom, DSM Pharma Chemicals Regensburg GmbH, D-93055 Regensburg, Germany |
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| Abstract: | A general, practical and efficient one-pot synthesis of cyclic enecarbamates is described. The protocol proceeds via reduction of lactam carbamate with Super-Hydride®, followed by in situ dehydration with trifluoroacetic anhydride (TFAA) and diisopropylethylamine (DIPEA). |
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