A domino ring-closing metathesis as a key-step in the synthesis of chiral lactones from d-mannitol |
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| Authors: | Bastien Nay Nicolas Gaboriaud-Kolar Bernard Bodo |
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| Affiliation: | Laboratoire de Chimie et Biochimie des Substances Naturelles—UMR 5154 CNRS, Muséum National d’Histoire Naturelle, 63 rue Buffon, 75005 Paris, France |
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| Abstract: | Chiral lactones were synthesized in six steps from d-mannitol. The key-step was a domino ring-closing metathesis reaction leading to the symmetric cleavage of a d-mannitol triene derivative and to the formation of two molecules of the desired lactone. |
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| Keywords: | Domino metathesis Chiral pool Lactones |
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