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Suzuki coupling for protein modification
Authors:Akio Ojida
Affiliation:PRESTO (Synthesis and Control, JST), Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Fukuoka 812-8581, Japan
Abstract:Suzuki-coupling, a representative cross-coupling reaction between small molecules, can proceed on a protein surface in aqueous solution under mild conditions. The modified protein produced by the coupling reaction maintained its native like structure and function. In addition, fluorescent dye appended-protein acts as a fluorescent biosensor.
Keywords:Suzuki coupling   Protein   Modification   Fluorescent biosensor
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