Acceleration of the Passerini reaction in the presence of nucleophilic additives |
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| Authors: | Maxim A Mironov Maria N Ivantsova Maria I Tokareva Vladimir S Mokrushin |
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| Institution: | Department of Technology of Organic Synthesis (TOSLab), Urals State Technical University, 620002 Ekaterinburg, Russian Federation |
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| Abstract: | An accelerating effect of nucleophilic additives was revealed for the Passerini multi-component reaction. The influence of aqueous solutions on the reaction rate was studied in detail and the direct involvement of water in the bond-making step was attributed as the basis of an accelerating effect. Other nucleophiles were tested as alternatives to water; as a result N-hydroxysuccinimide is proposed as an accelerant of the Passerini reaction. |
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| Keywords: | Passerini reaction Catalysis Aqueous solutions Nucleophilic additives Isocyanides |
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