An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves |
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| Authors: | Edith Gelens Leo A.J.M. Sliedregt Chris G. Kruse Romano V.A. Orru |
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| Affiliation: | a Department of Chemistry, Faculty of Exact Sciences, Vrije Universiteit, Amsterdam, The Netherlands
b Solvay Pharmaceutical Research Laboratories, Weesp, The Netherlands |
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| Abstract: | An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. |
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| Keywords: | Amides Synthesis Solvent free Microwave |
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