|
|||||
|
|
First organophosphorus radical-mediated cyclisations to afford medium-sized rings: eight-membered lactones and seven- and eight-membered lactams |
|
| Authors: | Stuart Lang Neil Muir Franziska Schönebeck Andrew H Payne |
| Institution: | a Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK b GlaxoSmithKline New Frontiers Science Park, Third Avenue, Harlow, Essex CM 19 5AW, UK c Eli Lilly and Company Ltd, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK |
| Abstract: | The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields. |
| Keywords: | Radical Phosphorus DEPO EPHP Cyclisation |
| 本文献已被 ScienceDirect 等数据库收录！ | |