Synthesis of a N-glycan nonasaccharide of the bisecting type with additional core-fucose |
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Authors: | Ralf Schuberth |
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Institution: | Bioorganische Chemie, Gebäude NWI, Universität Bayreuth, 95440 Bayreuth, Germany |
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Abstract: | A chemical synthesis was developed for N-glycans substituted with core-fucose and an additional bisecting GlcNAc (LEC10 motif). The synthesis was conducted using a suitably functionalized N-glycan pentasaccharide assembled from modular building blocks. Selective introduction of the bisecting GlcNAc residue was followed by attachment of the α1,6-arm and core-fucose. After introduction of an aminohexanoyl spacer the nonasaccharide was completely deprotected providing a substrate for enzymatic elongation and conjugation to proteins for further biological studies. |
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Keywords: | N-Glycan Bisecting Core-fucose Glycoprotein Oligosaccharide |
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