Straightforward Synthesis of (R,S)-β-Methyleneaspartic Acid, an Inhibitor of Glutamate-Aspartate Transaminase |
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| Authors: | Roberta Galeazzi Gianluca Martelli Mario Orena Samuele Rinaldi |
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| Institution: | (1) Dipartimento di Scienze dei Materiali e della Terra – Università Politecnica delle Marche – Via Brecce Bianche, 60121 Ancona, Italy |
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| Abstract: | Summary. A Baylis-Hillman adduct of methyl acrylate and ethyl glyoxalate was converted into the trichloroacetimidate that in the presence of DABCO rearranged to the corresponding trichloroacetamide. Eventually, hydrolysis under acidic conditions, led to the hydrochloride
of racemic β-methyleneaspartic acid. |
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| Keywords: | , Amino acid, Enzymes, Rearrangement, Baylis-Hillman, Dehydroamino acids, |
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